League injury log -- National League
Regular season -- as of 8/13/1881
| Injuries |
| Date | # | Team | Player | Cause | Dur |
| 5/3/1881 | | SBB | Cassidy | General | 5 |
| 5/3/1881 | | SBB | Creamer | General | 3 |
| 5/10/1881 | | FY | Whitney | Rain delay | 0 |
| 5/10/1881 | | RMB | McCormick | Rain delay | 0 |
| 5/13/1881 | | CW | Powell | General | 2 |
| 5/23/1881 | | PS | Sutton | General | 0 |
| 5/27/1881 | | PS | Knight | General | 2 |
| 5/30/1881 | | FY | Whitney | General | 5 |
| 6/4/1881 | | MM | Williamson | Rain delay | 0 |
| 6/8/1881 | | CW | Bradley | General | 3 |
| 6/8/1881 | | RMB | McCormick | General | 5 |
| 6/9/1881 | | CW | Ewing | General | 2 |
| 6/9/1881 | | RMB | Glasscock | General | 0 |
| 6/10/1881 | | MM | Dickerson | General | 0 |
| 6/10/1881 | | RMB | Stovey | General | 1 |
| 6/11/1881 | | MM | Connor | General | 0 |
| 6/13/1881 | | FY | Whitney | General | 5 |
| 6/16/1881 | | MM | York | General | 0 |
| 6/18/1881 | | RMB | Burdock | General | 2 |
| 6/20/1881 | | FY | Whitney | General | 5 |
| 6/24/1881 | | MM | Galvin | General | 5 |
| 6/24/1881 | | CW | Burns | General | 3 |
| 6/25/1881 | | MM | Morrill | General | 5 |
| 6/25/1881 | | MM | Barnes | General | 1 |
| 6/29/1881 | | RMB | Bennett | General | 2 |
| 7/4/1881 | | PS | Sutton | General | 0 |
| 7/4/1881 | | CW | Gross | General | 1 |
| 7/5/1881 | | FY | O'Rourke | General | 4 |
| 7/6/1881 | | PS | Anson | General | 0 |
| 7/8/1881 | | PS | Houck | General | 0 |
| 7/8/1881 | | SBB | Creamer | General | 2 |
| 7/11/1881 | | RMB | Goldsmith | General | 1 |
| 7/12/1881 | | MM | Williamson | General | 6 |
| 7/12/1881 | | PS | Anson | General | 0 |
| 7/12/1881 | | PS | Phillips | General | 2 |
| 7/13/1881 | | MM | York | General | 0 |
| 7/13/1881 | | RMB | Glasscock | General | 3 |
| 7/13/1881 | | RMB | Hankinson | General | 0 |
| 7/14/1881 | | CW | Gross | Collision in field | 0 |
| 7/14/1881 | | RMB | Burdock | General | 0 |
| 7/16/1881 | | MM | Nolan | General | 8 |
| 7/16/1881 | | SBB | Start | General | 1 |
| 7/18/1881 | | CW | Ward | General | 5 |
| 7/19/1881 | | FY | Whitney | General | 0 |
| 7/20/1881 | | FY | Hines | General | 0 |
| 7/20/1881 | | FY | Gillespie | General | 3 |
| 7/20/1881 | | MM | Gore | Collision on bases | 8 |
| 7/26/1881 | | RMB | Dorgan | Collision on bases | 12 |
| 7/29/1881 | | SBB | Corcoran | General | 0 |
| 7/29/1881 | | CW | Ewing | General | 0 |
| 7/30/1881 | | PS | Derby | General | 5 |
| 7/30/1881 | | SBB | Peters | General | 0 |
| 8/3/1881 | | FY | Hines | General | 0 |
| 8/3/1881 | | SBB | Creamer | General | 4 |
| 8/4/1881 | | PS | Hanlon | General | 3 |
| 8/5/1881 | | CW | Wood | General | 0 |
| 8/5/1881 | | FY | Whitney | Rain delay | 0 |
| 8/5/1881 | | SBB | Corcoran | Rain delay | 0 |
| 8/9/1881 | | RMB | Hankinson | General | 8 |
| 8/12/1881 | | FY | Caskin | General | 1 |
| 8/12/1881 | | CW | Ward | General | 0 |